Studies

Studies & Scientific Research

Hydrogen-rich Water

Bones :

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells - PubMe

Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats - PubMed

Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast - PubMed

Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis - PubMed

Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats - PubMed

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide - PubMed

Molecular hydrogen inhibits lipopolysaccharide_interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages - PubMed

Hydrogen water consumption prevents osteopenia in ovariectomized rats - PubMed

Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin - PubMed

Hydrogen supplementation of preservation solution improves viability of osteochondral grafts - PubMed

Hydrogen may inhibit collagen-induced platelet aggregation_ an ex vivo and in vivo study - PubMed

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials - PubMed

Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries - PubMed

Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model - PubMed

Brain

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis - PubMed

Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock - PubMed

The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats - PubMed

The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest - PubMed

The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles - PMC

Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water _ SpringerLink

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia_ initial clinical studies - PubMed

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress - PubMed

Protective effects of hydrogen on fetal brain injury during maternal hypoxia - PubMed

Protective effect of hydrogenrich medium against high glucoseinduced apoptosis of Schwann cells in vitro - Search Results - PubMed

Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet - PubMed

Pilot study of H2 therapy in Parkinson_s disease_ A randomized double‐blind placebo‐controlled trial - Yoritaka - 2013 - Movement Disorders - Wiley Online Library

Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats - PubMed

Oral _hydrogen water_ induces neuroprotective ghrelin secretion in mice - PubMed

Nuclear factor-κB_Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits - PubMed

Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model - PubMed

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia_Reperfusion Rats_ Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression - PubMed

Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning - PubMed

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage_ Possible Role of the Akt_GSK3β Signaling Pathway - PMC

Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood - PubMed

Cancer

Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer - PubMed

Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells - PMC

Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum nanoparticles _ SpringerLink

Suppression of Invasion of Cancer Cells and Angiogenesis by Electrolyzed Reduced Water - ProQuest

Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen - PubMed

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy - PubMed

Platinum nanocolloid supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells - PubMed

On the antitumor properties of biomedical magnesium metal - Journal of Materials Chemistry B (RSC Publishing)

Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice _ SpringerLink

Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy _ Scientific.Net

Magnesium metal—A potential biomaterial with antibone cancer properties - Nan - 2014 - Journal of Biomedical Materials Research Part A - Wiley Online Library

Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging - PubMed

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis - PubMed

Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells _ Scientific.Net

Hyperbaric hydrogen therapy_ a possible treatment for cancer - PubMed

Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer - PubMed

Hydrogen gas inhibits lung cancer progression through targeting SMC3 - PubMed

Growth Suppression of HL60 and L6 Cells by Atomic Hydrogen _ SpringerLink

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione - PubMed

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione - PubMedElectrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation - PubMed

Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells _ SpringerLink

Eye & Ear

The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against N-Methyl- N-Nitrosourea Induced Retinal Degeneration_ A Topographic Study - PubMed

Suppression of glutamate-induced neural cell death by electrolyzed-reduced water _ SpringerLink

Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats - PubMed

Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration - PubMed

Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model - PubMed

Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats - PMC

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina - PubMed

Protection of the retina by rapid diffusion of hydrogen_ administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury - PubMed

Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil - PubMed

Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia_reperfusion injury - PubMed

Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss - PubMed

Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress - Search Results - PubMed

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species - PubMed

Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils - PubMed

Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect - PubMed

Heart

Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice - PubMed

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans - PubMed

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion - PubMed

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin - PubMed

Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats - PubMed

Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats - PubMed

Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice - PubMed

Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2_HO-1 signaling pathway - PubMed

Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model - PubMed

Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine - PubMed

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice - PubMed

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats - PubMed

Improving outcomes from resuscitation_ from hypertension and hemodilution to therapeutic hypothermia to H2 - PubMed

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K_Akt signaling pathway during cardiopulmonary bypass in rats - PubMed

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration - PubMed

Human Studies

Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients_ a novel approach to suppress oxidative stress in the peritoneal cavity _ Medical Gas Research _ Full Text

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis_ a randomized, double-blind, placebo-controlled pilot study - PubMed

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance - PubMed

Selective protective effect of hydrogen water on free radical injury of athletes after high-intensity exercise

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease - PubMed

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia_ initial clinical studies - PubMed

Relationship between Exhaled Hydrogen and Human Neutrophi... - Google Scholar

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy - PubMed

Pilot study_ Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes - PubMed

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques - PubMed

Liver

The protective role of hydrogen-rich saline in experimental liver injury in mice - PubMed

The protective role of hydrogen-rich saline against... - Google Scholar

Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents - PubMed

Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats - PubMed

Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release - PubMed

Protective effect of intraportal infusion of hypothermic... - Google Scholar

Preadministration of Hydrogen-Rich Water Protects Against Li... _ Shock

Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death_ a preliminary study _ SpringerLink

Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats - PubMed

Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells - PubMed

Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine - PubMed

Inhalation of high concentrations of hydrogen ameliorates liver ischemia_reperfusion injury through A2A receptor mediated PI3K-Akt pathway - ScienceDirect

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice - PMC

Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice

Lungs & Other Organs

The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death - PubMed

The Anti-inflammatory Effect of Hydrogen on Lung Transplanta... _ Transplantation

Stimulation of human damaged sperm motility with hydrogen molecule - PubMed

Saturated hydrogen saline protects the lung against oxygen toxicity - PubMed

Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock - PMC

Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis - PMC

Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats - PMC

Miscellaneous

_i_In Vitro__i_ Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives [Regulative effects of hydrogen-rich medium on monocytic adhesion and va

Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD) - PubMed

Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2_-bipyridyl methods - PubMed

Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions _ SpringerLink

Biological toxicity of acid electrolyzed functional water_ effect of oral administration on mouse digestive tract and changes in body weight - PubMed

Cathodic amelioration of the adverse effects of oxidative stress accompanying procedures necessary for cryopreservation of embryonic axes of recalcitrant-seeded species _ Seed Science Research _ Cambridge Core

Concentration determination of oxygen nanobubbles in electrolyzed water - PubMed

Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats - PubMed

Effect of electrolyzed water on wound healing - PubMed

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses - PubMed

Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect_ a feeding test with rats - PubMed

Electrolyzed Reduced Water Prolongs Caenorhabditis elegans’ Lifespan _ SpringerLink

Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein - PubMed

Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage - PubMed